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Clinic Observation of the Treatment of Rheumatoid arthritis with Thalidomide
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.11.001
- Key Word:
- 类风湿性关节炎;沙利度胺;甲氨蝶呤
Abstract： 目的 探讨沙利度胺单独及联合甲氨蝶呤治疗类风湿性关节炎的疗效及安全性.方法 54例类风湿性关节炎(RA)患者随机分成2组,沙利度胺组20例,沙利度胺+甲氨蝶呤组34例,持续治疗3个月;每月复查疼痛关节数、肿胀关节数及晨僵出现率等临床指标及血沉和C-反应蛋白等实验室指标,所有病例随访3～8个月.结果 沙利度胺组的总有效率为60%,沙利度胺+甲氨蝶呤组的总有效率为82.35%,2组之间无统计学意义;治疗前后2组各项指标比较均有统计学意义(P＜0.01),治疗后2组各项指标中仅疼痛关节数有统计学意义(P＜0.01);2组分别有45%和67.41%的患者有药物不良反应,但无统计学意义,症状均比较轻微,可以耐受.结论 两种方案对类风湿性关节炎均有效,甲氨蝶呤与沙利度胺有协同作用,且安全性较高.
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