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Relationship between PON2、ApoE gene polymorphisms and type 2 diabetic nephropathy
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.07.001
- Key Word:
- 2型糖尿病;糖尿病肾病;对氧磷脂酶2;载脂蛋白E
Abstract： 目的 探讨对氧磷脂酶2(PON2)基因S311C及载脂蛋白(ApoE)基因变异单独及联合作用对2型糖尿病肾病的影响.方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测福建地区210例.2型糖尿病(T2DM)患者(113例糖尿病肾病患者,97例糖尿病非肾病患者)和105例健康对照者的PON2基因S311C及ApoE基因多态性.结果 ①糖尿病肾病组PON2 CC基因型及C等位基因和ApoE ε3/4+ε4/4基因型及ε4等位基因频率明显高于糖尿病非肾病组及正常对照组(P＜0.05);②SC+CC与ε3/4+ε4/4基因型并存时对糖尿病肾病的发生具有协同效应(x2=20.89,P=0.00);③T2DM患者中CC及ε3/4+ε4/4基因型有较高的总胆固醇、低密度脂蛋白水平(P＜0.05);④Logisitic回归分析表明:CC及ε3/4+ε4/4基因型是糖尿病肾病发生的独立变异危险因素(P＜0.05).结论 PON2、ApoE基因多态性可通过血脂代谢紊乱而影响2型糖尿病肾病的发生.
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