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The levels of serum c-reactive protein in patients with congestive heart failure and the effects of Lipitor
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.05.006
- Key Word:
- 充血性心力衰竭;C-反应蛋白;立普妥
Abstract： 目的 研究充血性心力衰竭(CHF)患者血清中C-反应蛋白(CRP)水平及与心功能的关系,并观察立普妥对CRP的影响.方法 入选66例CHF患者(NYHAⅡ～Ⅳ级),30例正常对照者;应用免疫比浊法测定血清CRP水平,采用超声心动图测量左心室射血分数(LVEF).次日晨检测血清CRP,3 d内行超声心动图检查.CHF组随机分为立普妥组、常规治疗组,所有CHF患者均给予常规治疗,立普妥组加服立普妥10 mg/d,8周后复查血清CRP.结果 CHF组较正常对照组血清CRP水平明显增高(P＜0.01),并且随NYHA心功能级别增高,血清CRP水平明显升高(P＜0.01).血清CRP浓度与LVEF呈负相关(r=-0.571,P＜0.01).CHF患者经治疗,立普妥组血清CRP水平的下降比常规治疗组更为显著(P＜0.01). 结论①心力衰竭患者血清CRP水平增高,并且心力衰竭越重,CRP水平越高,血清CRP水平和左心室射血分数呈负相关;②立普妥能降低CHF患者的CRP水平.
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