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Efficacy and safety of kasiping and sulfonylurea in the treatment of type 2 diabetes mellitus
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.04.001
- Key Word:
- 卡司平;磺脲类;2型糖尿病
Abstract： 目的 观察卡司平与磺脲类药物联合治疗2型糖尿病临床疗效与安全性.方法 30例2型糖尿病患者应用卡司平联合磺脲类治疗,另30例单用磺脲类治疗作对照,共8周,观察2组治疗前后血糖、糖化血红蛋白(HbA1c)、空腹胰岛素、血脂、血压的变化.结果 联合用药组治疗后患者空腹血糖(FPG)、餐后2 h血糖(2hPG)明显下降(P均＜0.01),糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平均有显著下降(P＜0.05),胰岛素抵抗指数(HOMA指数)下降(P＜0.01).甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)下降(P＜0.01),肝、肾功能无明显变化.结论 卡司平与磺脲类药物联合治疗2型糖尿病明显降低空腹血糖、餐后2 h血糖及糖化血红蛋白,且无肝肾副作用,有良好的安全性.
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