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Effect of morphine on the critical hypoxemic respiratory failure patients receiving noninvasive mechanical ventilation
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.02.004
- Key Word:
- 呼吸衰竭;无创机械通气;吗啡
Abstract： 目的 观察急性低氧性呼吸衰竭患者无创机械通气(NIMV)过程中吗啡对通气疗效的影响.方法 16例伴有精神症状的急性呼吸衰竭患者NIMV时静脉注射吗啡,使之处于Ramsay镇静评分2～4分水平,比较治疗前后呼吸频率(RR)、动脉血气分析(PaO2、PaCO2、SaO2)、心率(HR)、平均动脉压(MAP)、呼气潮气量(VT)及分钟通气量(VE).结果 患者镇静治疗后,HR和MAP水平稳定,氧合指标(PaO2、PaO2/FiO2)显著改善(P＜0.005);PaCO2平均升高(6.7±1.1)mm Hg,变化不显著(P＞0.05);RR减慢(P＜0.05);呼气VT无明显变化(P＞0.05);VE下降(P＜0.05).结论 急性低氧性呼吸衰竭患者NIMV时合理使用镇静剂可改善氧合状态,不引起严重二氧化碳潴留.
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