You Position: Home > Paper
IL-8 and G-CSF in patients with helicobacter pylori infection.
( views:70, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.01.005
- Key Word:
- 幽门螺杆菌;白细胞介素-8;粒细胞集落刺激因子;酶联免疫吸附试验
Abstract： 目的 探讨胃黏膜白细胞介素-8(IL-8)和粒细胞集落刺激因子(G-CSF)含量与幽门螺杆菌(Hp)感染的关系.方法 应用酶联免疫吸附试验法测定56例接受胃镜检查患者胃窦黏膜组织培养上清中IL-8、G-CSF的含量,比较感染与非感染患者、感染者治疗前后之间的差异.结果 56例中38例Hp感染的胃黏膜IL-8及G-CSF含量明显高于18例非Hp感染者(P＜0.01).Hp根除后IL-8及G-CSF含量明显低于根除前(P＜0.01).结论 Hp感染可以诱导胃黏膜炎症细胞合成和释放IL-8及G-CSF,IL-8及G-CSF可能在Hp相关胃疾病的发病过程中发挥关键作用,是引起炎症反应以及进一步病理损害的重要途径.
- [1]陈洁,虞燕萍,黄晓磊,等.Hp感染儿童胃十二指肠粘膜IL-8及IL-8 mRNA的研究[J].2003,(3).
- [2]刘炯,许国铭.幽门螺杆菌感染与IL-8表达的关系[J].1999,(12).
- [3]J M, Martín Guerrero,P, Hergueta Delgado,J J, Esteban Carretero,etc.Pathogenic implications of interleukin-8 activity and bacterial phenotype in antral gastritis associated with Helicobacter pylori.[J].2000,92(5).
- [4]M, Baggiolini,B, Dewald,B, Moser.Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.[J].1994,55.
- [5]J E Crabtree,T M Shallcross,R V Heatley,etc.Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.[J].1991,32(12).
- [6]Yasuhiro Fujiwara,Tetsuo Arakawa,Takashi Fukuda,etc.Interleukin-8 Stimulates Leukocyte Migration Across a Monolayer of Cultured Rabbit Gastric Epithelial Cells (Effect Associated with the Impairment of Gastric Epithelial Barrier Function)[J].1997,42(6).
- [7]G, Rieder,R A, Hatz,A P, Moran,etc.Role of adherence in interleukin-8 induction in Helicobacter pylori-associated gastritis.[J].1997,65(9).