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Study of the changes of cytokine network and their relationships with cardiac function in patients with chronic heart failure
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.12.001
- Key Word:
- 慢性心力衰竭;肿瘤坏死因子-α;白细胞介素-6;转化生长因子-β1
Abstract： 目的 观察肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、转化生长因子-β1(TGF-β1)在慢性心力衰竭(CHF)患者中的变化及其与心功能的相互关系.方法 抽取49例基础疾病为缺血性心脏病、扩张型心肌病及高血压性心脏病的CHF患者和30例健康体检者的血清,用放射免疫法测定TNF-α、IL-6,用酶联免疫法测定TGF-β1,超声心动图测定左心室射血分数,并进行比较分析.结果 cHF患者血清TNF-α和IL-6水平明显高于正常对照组(P＜0.01),并与左心室射血分数成显著负相关(r=-0.823,P＜0.01;r=-0.851,P＜0.01).TGF-β1水平明显低于正常对照组(P＜0.01),并与左心室射血分数成显著正相关(r=0.814,P＜0.01).且心力衰竭程度越重,上述变化越明显.结论 CHF患者血清中TNF-α、IL-6和TGF-β1水平与患者的心功能有明显的相关性,失衡的细胞因子网络可能参与了CHF的发生和发展.细胞因子的浓度可以作为cHF患者临床评估的参考指标.
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