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T cells regulatory function in Alzheimer's Disease
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.08.006
- Key Word:
- 阿尔茨海默病;调节性T细胞;混合淋巴细胞反应
Abstract： 目的 对阿尔茨海默病(AD)患者外周血调节性T细胞功能进行研究.方法 流式细胞仪测定T细胞亚群;细胞分选仪分离调节性T细胞,体外培养行淋巴细胞混合培养法检测调节性T细胞对同源/异源淋巴细胞增殖的抑制效应;ELISA法检测调节性T细胞细胞因子肿瘤坏死因子-β、白细胞介素-10的分泌水平.结果 CD4+CD25+调节性T细胞细胞比例和健康对照组相比差异无显著性.肿瘤坏死因子-β、白细胞介素-10的分泌2组间差异无显著性.AD组调节性T细胞抑制功能受损,与对照组有明显差异.结论 AD患者调节性T细胞抑制功能受损,可能与其接触抑制途径缺陷有关.
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