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Investigation on the correlation between serum interleukin-2 level and cardiovascular disease in patients with chronic kidney disease
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.07.001
- Key Word:
- 慢性肾脏病;白细胞介素-2;肾功能;心血管病变
Abstract： 目的探讨慢性肾脏病(CKD)患者血清白细胞介素-2(IL-2)水平及临床意义.方法按照NKF-K/DOQI标准,采用酶联免疫法对61例CKD患者和正常对照组(25例)测定血清IL-2含量,并检测相关临床指标,分析血清IL-2水平与肾功能、心血管病变及其他临床资料的关系.结果CKD组患者血清IL-2含量较正常对照组显著升高(P＜0.05),肾功能3、4、5级患者血清IL-2水平较肾功能1、2级显著升高(P均＜0.05);相关分析显示CKD患 者血清IL-2水平与血肌酐呈显著正相关(r=0.412,P＜0.05),与内生肌酐清除率呈显著负相关(r=-0.326,P＜0.05).CKD心血管病变组血清IL-2水平明显高于无心血管病变组(P＜0.01),高血清IL-2组心血管病变发生率显著高于正常血清IL-2组(P＜0.01).结论CKD患者血清IL-2水平升高,与肾功能减退时严重代谢紊乱引起的T细胞活化有关.IL-2升高本身可能作为损伤因子,参与肾功能恶化,并与心血管病变的发生有关.
- [1]Heemann U,Flach R,Peti-Peterdi J,etc.Interleukin-2-dependent mechanisms are involved in the development of glomerulosclerosis after partial renal ablation in rats.[J].2001,9(2).
- [2]Schaefer EJ.,Meydani SN.,Han SN.,etc.Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia[J].2002,43(3).
- [3]Christmas S,Slavin J,Bhatia M,etc.Inflammatory mediators in acute pancreatitis.[J].2000,190(2).