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Endothelial function and insulin resistance as well as secretion function of insulin in patients with different glucose glycometabolism
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.04.011
- Key Word:
- 内皮功能;胰岛素抵抗;胰岛素分泌;糖代谢
Abstract： 目的研究不同糖代谢状态血管内皮功能和胰岛素抵抗、胰岛素分泌功能及其相互关系.方法初诊2型糖尿病组47例,糖调节受损组89例,正常糖耐量组137例.采用高分辨率血管外超声法检测肱动脉血管血流介导的内皮依赖性血管舒张功能(EDD)和硝酸甘油介导的内皮非依赖性血管舒张功能(NTG),并应用胰岛素抵抗指数评价胰岛素抵抗,B细胞功能指数、△I30/△G30分别评价基础状态下及糖负荷后的早期胰岛素分泌功能.结果初诊2型糖尿病组和糖调节受损组EDD较正常糖耐量组显著降低,分别为6.16±2.92,7.87±3.19和9.32±3.46(P＜0.05～0.01),初诊2型糖尿病组又低于糖调节受损组(P＜0.05).初诊2型糖尿病组和糖调节受损组HOMA-IR显著升高(P均＜0.01),△I30/△G30显著降低(P＜0.05～0.01),后者在初诊2型糖尿病组降低更明显(P＜0.05).初诊2型糖尿病组HOMA-B显著降低(P＜0.05).EDD与HOMA-IR负相关(r=-0.301,P＜0.01),与△I30/△G30正相关(r=0.418,P＜0.01).结论糖代谢紊乱早期即可见内皮功能障碍,后者主要与胰岛素抵抗和早期胰岛素分泌缺陷相关.
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