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Effect of perindopril in maintenance of sinus rhythm after cardioversion of aterial fibrillation (AF) and its influence on left atrial function
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.02.003
- Key Word:
- 心房颤动;培哚普利;超声心电图描记术;左心房功能
Abstract： 目的 探讨培哚普利联用胺碘酮在持续性心房颤动转复后维持窦性心律的作用及对左心房功能的影响.方法 102例持续性心房颤动患者,经药物或电复律后随机分为两组,Ⅰ组52例给予胺碘酮0.2 g,1次/d;Ⅱ组50例给予培哚普利4 mg,1次/d,胺碘酮0.2 g,1次/d;两组均连服6个月.分别于治疗后第1周、2周,1、2、4及6个月复查心电图或动态心电图,观察心房颤动复发情况;复律后次日及6个月后做超声心动图检查,观察左心房功能变化.结果 共89例完成治疗.随访6个月,心房颤动复发Ⅰ组为34.1%(15/44),Ⅱ组为13.3%(6/45),两组比较差异有显著性(P＜0.05);Ⅱ组复律后次日及治疗6个月后,超声测量左心房内径由(42±12)mm缩小为(34±11)mm,治疗前与治疗6个月后比较差异有显著性(P＜0.01),而Ⅰ组上述指标比较差异无显著性(P＞0.05).结论 培哚普利联用胺碘酮在持续性心房颤动转复后维持窦性心律,较单用胺碘酮更有效,长期服用培哚普利可逆转左心房扩大,降低左心房压,有利于消除心房颤动复发的基础因素.
- [1]林菁,孙照霞,包成梅.胺碘酮的不良反应[J].2002,(6).
- [2]顾卫霞.卡托普利对急性心肌梗死合并心房颤动患者的疗效观察[J].2005,(9).
- [3]Y, Shi,A, Ducharme,D, Li,etc.Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation.[J].2001,52(2).
- [4]Thomas Everett,Hui Li,J. Mangrum,etc.Electrical, Morphological, and Ultrastructural Remodeling and Reverse Remodeling in a Canine Model of Chronic Atrial Fibrillation[J].2000,102(12).
- [5]Jun, Xu,Guanggen, Cui,Fardad, Esmailian,etc.Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation.[J].2004,109(3).
- [6]W M, Feinberg,J L, Blackshear,A, Laupacis,etc.Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications.[J].1995,155.
- [7]H, Nakashima,K, Kumagai,H, Urata,etc.Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation.[J].2000,101(22).