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Effect of valsartan on perioperational levels of endothelial-1 and nitric oxide in congenital heart disease patients complicated with pulmonary hypertension
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4777.2006.01.001
- Key Word:
- 先天性心脏病;缬沙坦;内皮素;一氧化氮
Abstract： 目的 探讨缬沙坦对先天性心脏病肺动脉高压患者围术期血内皮素(ET-1)、一氧化氮(NO)及平均肺动脉压(MPAP)、肺血管阻力(PVR)的影响.方法 将52例室间隔缺损合并中、重度肺动脉高压患者随机分为4组.Ⅰ组为对照组,Ⅱ组为卡托普利治疗组,Ⅲ组为缬沙坦治疗组,Ⅳ组为缬沙坦加卡托普利治疗组.分别于入院后(T1)、麻醉诱导后手术前(T2)、手术结束(T3)、术后6 h(T4)、术后24 h(T5)、术后48h(T6)测定血ET-1、NO及MPAP、PVR.结果 四组之间ET、NO、MPAP、PVR差异有显著性(P＜0.05).与Ⅰ组比较,Ⅱ组T2、T3、T5,Ⅲ组及Ⅳ组T2至T6时间点ET-1水平显著低于Ⅰ组(P＜0.05);Ⅲ组T2、T3、T5、T6,Ⅳ组T2、T3、T5时间点NO水平显著高于Ⅰ组(P＜0.05).与Ⅱ组比较,Ⅲ组T3,Ⅳ组T3、T5时间点ET-1水平显著低于Ⅱ组(P＜0.05).与Ⅰ组比较,Ⅱ组T5,Ⅲ组T4、T5、T6,Ⅳ组T5、T6时间点MPAP水平显著低于Ⅰ组(P＜0.05);Ⅱ组T3至T6,Ⅲ组及Ⅳ组T2至T6时间点PVR水平显著低于Ⅰ组(P＜0.05).与Ⅱ组比较,Ⅲ组及Ⅳ组T6时间点MPAP水平显著低于Ⅱ组;Ⅲ组T5、T6,Ⅳ组T3至T6时间点PVR水平显著低于Ⅱ组(P＜0.05).结论 缬沙坦有降低先天性心脏病肺动脉高压患者血ET-1水平,增加NO的浓度,并降低肺动脉压力和肺血管阻力的作用.
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