Distribution and drug resistance of major pathogens for urinary tract infections

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Author:
QIU Sheng-feng(Clinical Laboratory, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial Women and Children Hospital, Nanfing 210036, China)
PAN Shi-yang()
GU Bing()
ZHANG Mei-juan()
LI Qing()
Journal Title:
Chinese Journal of Clinical Infectious Diseases
Issue:
Volume 05, Issue 02, 2012
DOI:
10.3760/cma.j.issn.1674-2397.2012.02.003
Key Word:
Urogenital system;Gram-negative bacteria;Gram-positive bacteria;Fungi;Infection

Abstract: Objective To investigate the distribution and drug resistance of major pathogens for urinary tract infections in the First Affiliated Hospital of Nanjing Medical University.Methods Strains from midstream urine culture of patients with urinary tract infections were collected during January 1 and December 31,2011.All strains were identified by API system,and disk diffusion method was used for drug sensitivity test.Results Totally 1129 strains were isolated,in which 667 (59.1% ) were Gram-negative strains,266 (23.5%) were Gram-positive strains,and 196 (17.4) were Candida.Among Gram-negative strains,Escherichia coli,Klebsiella pneumoniae and Proteus mirabilis were highly sensitive to carbapenem antibiotics; while Acinetobacter baumannii and Pseudomonas aeruginosa were highly resistant to most antibiotics including cephalosporins and penicillinase inhibitor,and the resistance rates were over 50%.Among Gram-positive strains,the major strains Enterococcus avium and Enterococcusfaecalis were completely sensitive to vancomycin and teicoplanin,and highly sensitive to linezolid (resistance rate below 10% ).Candida albicans and Candida glabrata were highly resistant to voriconazole and fluconazole (with the resistance rates of 47.2% - 60.0% ), but were completely sensitive to amphotericin and nystatin.Conclusion Gram-negative strains account for most urinary tract infections in the First Affiliated Hospital of Nanjing Medical University with high drug resistance rates.

  • [1]陈灏珠.实用内科学.11版.北京:人民卫生出版社,2003:2043-2045.
  • [2]叶应妩,王毓三,申子瑜.全国临床检验操作规程.3版.南京:东南大学出版社,2006:754-883.
  • [3]Clinical and Laboratory Standards Institute. M100-S20 Performance standards for antimicrobial susceptibility testing;twentieth informational supplemant.Wayne Pennsylvania,2010.
  • [4]张云霞,李刚,贾伟.559株假丝酵母菌的鉴定及药物敏感性分析.宁夏医科大学学报,2010,32(1):123-124.
  • [5]邵敏伟,梁艳,周庭银.2991份中段尿培养病原菌种类分布与耐药性分析.中华医院感染学杂志,2009,19 (15):2044-2047.
  • [6]吴巧生,陈维红,李志宏.某院2005~ 2007年手术科室住院患者抗菌药物应用合理性调查.中国药房,2010,21(2):112-115.
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