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Research progress on prenatal vertical transmission of hepatitis B virus and its interruption

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-2397.2010.06.021

Key Word:: 肝炎病毒,乙型;疾病传播,垂直;产前;阻断;Hepatitis B virus;Disease transmission,vertical;Prenatal;Interruption

Abstract： @@ 众所周知,垂直传播是感染乙型肝炎病毒(HBV)的重要途径之一,广义的垂直传播途径包括经生殖细胞、宫内感染、分娩及产后接触等,在时间上则可分为产前、产时和产后3个阶段.对产时、产后两种传播方式,现在通过联合使用乙型肝炎免疫球蛋白(HBIG)和乙型肝炎疫苗对新生儿进行主-被动联合免疫,已经使HBV感染率有了明显的下降,阻断率可达90%,但仍有10%左右的新生儿未能避免HBV感染,即免疫失败.因此研究HBV产前感染的危险因素、探索感染机制,是阻断和预防HBV垂直传播的关键.

Reference

[1]孟庆举,肖小敏.产前乙型肝炎病毒父婴垂直传播几率的Meta分析[J].2008,(5).
[2]叶峰,李淑红,陈天燕,等.乙型肝炎病毒在患者卵巢中的表达[J].2005,(12).
[3]朱启鎔,于广军,吕晴,等.阻断乙型肝炎病毒宫内传播的随机对照研究[J].2002,(8).
[4]朱萍,曾蔚越.孕期不同阶段应用HBIG阻断乙肝母婴传播效果初探[J].2007,(9).
[5]韩忠厚,钟连华,王佳,等.妊娠晚期孕妇注射乙型肝炎免疫球蛋白对其血清HBV DNA及新生儿抗-HBs的影响[J].2007,(5).
[6]王珊珊,李文玲,彭桂福,等.序列分析鉴定乙型肝炎病毒的父婴传播[J].2003,(5).
[7]白菡,丁洋,张琳,等.胎盘滋养层细胞的乙型肝炎病毒感染与宫内感染机制[J].2007,(11).
[8]Shu-Lin Zhang,Ya-Fei Yue,Gui-Qin Bai,etc.Mechanism of intrauterine infection of hepatitis B virus[J].2004,(3).
[9]张丽菊,王玲.替比夫定对妊娠后期乙型肝炎病毒宫内感染的阻断作用[J].2009,(8).
[10]李淑红,岳亚飞.外周血单个核细胞在乙肝病毒传播中的作用[J].2004,(5).
[11]闫永平,徐德忠,王文亮.胎盘乙型肝炎病毒感染与宫内传播的关系[J].1999,(7).
[12]晏路标,肖昕,熊爱华.胎盘Hofbauer细胞在乙型肝炎病毒母婴垂直传播中的作用[J].2006,(6).
[13]王爱莉,戴笙,初兆荣,等.乙肝病毒母婴垂直传播胎盘超微结构变化[J].2001,(1).
[14]何进球,袁松华,冼革坚,等.乙型肝炎病毒阳性父-婴垂直传播的临床研究[J].2005,(5).
[15]Song YM,Yang S,Choe YH,etc.Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus.[J].2007,166(8).
[16]Bahy,Ahmed,Ali,etc.Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome[J].2006,(3).
[17]M. Hadchouel,J. Scotto,J. L. Huret,etc.Presence of HBV DNA in spermatozoa: A possible vertical transmission of HBV via the germ line[J].1985,16(1).
[18]H H, Lin,T Y, Lee,D S, Chen,etc.Transplacental leakage of HBeAg-positive maternal blood as the most likely route in causing intrauterine infection with hepatitis B virus.[J].1987,111.
[19]Y. Lazizi,S. Badur,Y. Perk,etc.Selective unresponsiveness to HBsAg vaccine in newborns related with an in utero passage of hepatitis B virus DNA[J].1997,15(10).
[20]Kagimoto S,Mizokami M,Tokuhara D,etc.Molecular evidence of father-to-child transmission of hepatitis B virus.[J].2007,79(7).
[21]A B, van Nunen,R A, de Man,R A, Heijtink,etc.Lamivudine in the last 4 weeks of pregnancy to prevent perinatal transmission in highly viremic chronic hepatitis B patients.[J].2000,32(6).
[22]Holden S,Fraser MA,Wiseman E.Perinatal transmission of hepatitis B virus: an Australian experience.[J].2009,190(9).
[23]A S, Lok,E J, Heathcote,J H, Hoofnagle.Management of hepatitis B: 2000--summary of a workshop.[J].2001,120(7).
[24]Cui YT,Zhang SL,Campbell F,etc.Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study.[J].2009,16(2).
[25]门可,徐德忠,闫永平,等.血HBSAG、HBEAG阳性孕妇外周血单个核细胞HBV感染的研究[J].1996,(10).
[26]Gerlich WH.,Schaeffer S.,Kann M. Lampert F.,etc.Transcription of Hepatitis B Virus in Peripheral Blood Mononuclear Cells from Persistently Infected Patients[J].1997,71(7).