Expression of CD127 and its association with apoptosis of CD8 + T lymphocytes in patients with chronic HIV-1 infection

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Author:
JIN Lei(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
L(U) Ji-yun(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
XU Xiang-sheng(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
ZHANG Shu-ye(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
JIAO Yan-mei()
WU Hao()
WANG Xi-cheng()
ZHANG Zheng(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
WANG Fu-sheng(Research Center for Biological Therapy, the 302 Military Hospital of China, Beijing 100039, China)
Journal Title:
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
Issue:
Volume 03, Issue 04, 2010
DOI:
10.3760/cma.j.issn.1674-2397.2010.04.002
Key Word:
Interleukin-7 receptor alpha submit;Human immunodeficiency virus;CD8 + T lymphocytes;Apoptosis

Abstract: Objective To investigate the expression of CD127 (interleukin-7 receptor α, IL-7Rα)and its association with apoptosis of CD8 + T lymphocytes in patients with chronic HIV-1 infection. Methods The expression of CD127 on T lymphocytes and spontaneous apoptosis of CD8+ T lymphocytes were measured by flow cytometry in peripheral blood from 24 patients with chronic HIV-1 infections and 12 healthy subjects. The associations of CD127 expression with CD4 +T lymphocytes counts, HIV RNA loads and cell apoptosis were analyzed. Mann-Whitney U test was performed to compare between the groups, and Spearman test was used for correlation analysis. Results The expression of CD127 on CD8 + T lymphocytes was significantly down-regulated in HIV-1 infected subjects (Z = -4.796, P < 0. 01 ), which was positively correlated with CD4 + T lymphocytes (r = 0.817, P < 0.01 ) and negatively correlated with HIV RNA load and CD8+T lymphocytes apoptosis (r= -0.442 and -0.688,P<0.05 and <0.01). Conclusion CD127 down-regulation may play an important role in the descended ability of receiving survival signals and ascended apoptosis of CD8 + T lymphocytes during chronic HIV-1 infection, which indicates that IL-7 might be a novel strategy in treatment of HIV infection.

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