Distribution and drug resistance of pathogens in cancer patients with nosocomiai infection

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Author:
RUAN Yan-ping(Department of Hospital Infection Control,Zhejiang Cancer Hospital,Hangzhou 310022,China)
ZHANG Wen-ying(Department of Hospital Infection Control,Zhejiang Cancer Hospital,Hangzhou 310022,China)
MAO Cai-ping()
WANG Ming-li()
Journal Title:
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
Issue:
Volume 2, Issue 04, 2009
DOI:
10.3760/cma.j.issn.1674-2397.2009.04.005
Key Word:
Carcinoma;Nosocomial infection;Pathogen;Drug resistance

Abstract: Objective To investigate the distribution and drug resistance of pathogens in cancer patients with nosocomial infections. Methods Pathogens isolated from cancer patients with nosocomial infections in Zhejiang Cancer Hospital from 2004 to 2008 were analyzed. Results Totally 3454 strains of pathogens were isolated, including 1900 strains of Gram-negative bacilli (55.0%), 838 strains of fungi (24.3%), and 716 strains of Gram-positive bacteria (20.7%). Pathogenic bacteria Escherichia coli and Candida albicans were isolated mainly from surgical wound, urinary tract, respiratory tract and oral cavity. The drug resistant rates for Gram-negative Escherichia coli and Gram-positive staphylococci were high, and Candida albicans was sensitive to all antifungal drugs. Conclusion Opportunistic pathogens account for most nosocomial infections in cancer patients, and some of them are of high-level resistance to antimicrobial agents.

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