Liver fibrosis in 102 chronic hepatitis B patients with hepatic steatosis

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SHI Jun-ping(Department of Hepatology, Hangzhou Sixth People's Hospital, Zhejiang Chinese Medical University, Hangzhou 310014, China)
FAN Jian-gao()
WU Rui()
XUN Yun-hao(Department of Hepatology, Hangzhou Sixth People's Hospital, Zhejiang Chinese Medical University, Hangzhou 310014, China)
LOU Guo-qiang(Department of Hepatology, Hangzhou Sixth People's Hospital, Zhejiang Chinese Medical University, Hangzhou 310014, China)
Journal Title:
Volume 1, Issue 02, 2008
Key Word:
Chronic hepatitis B;Fatty liver;Liver fibrosis;Intlammation

Abstract: Objective To evaluate the prevalence of hepatic steatosis in patients with chronic hepatitis B (CHB) and the impact of hepatic steatosis on the progress of fibrosis. Methods Five hundred and sixty two untreated CHB patients (405 males and 157 females) with an average age of 31.3 underwent liver biopsy from January to August 2007. On the day of liver biopsy, a questionnaire was completed and a blood sample was obtained for laboratory analysis. The degree of liver steatosis, necroinflammation and fibrosis was assessed; demographic information and clinical data including age, gender, body mass index (BMI), history of diabetes mellitus, hypertension, dyslipidemia, and HBeAg status, HBV DNA viral load were documented. Results In 562 patients, 102 (18. 2% ) had steatosis. Multivariate analysis demonstrated that liver steatosis was associated with the levels of TG, APO-B, UA, FSG, and higher BMI; and the progress of fibrosis was associated with high degree of hepatic steatosis and necroinflammation, age over 35 years, HBV DNA > 103 copies/L, high BMI and GGT. Conclusions The results show that obesity and dyslipidemia in CHB patients are associated with the hepatic steatosis, and the latter seems to be an important determinant for fibrosis.

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