Abstract： Objective To investigate the marginal adaptation of crowns fabricated by selective laser melting( SLM ) and wax-lost-casting method,so as to provide an experimental basis for clinic.Methods Co-Cr alloy full crown were fabricated by SLM and wax-lost-casting for 24 samples in each group.All crowns were cemented with zinc phosphate cement and cut along longitudinal axis by line cutting machine.The gap between crown tissue surface and die was measured by 6-point measuring method with scanning electron microscope( SEM ). The marginal adaptation of crowns fabricated by SLM and wax-lost-casting were compared statistically.Results The gap between SLM crowns were (36.51 ±2.94),(49.36 ±3.31 ),( 56.48 ± 3.35 ),( 42.20 ± 3.60) μm,and wax-lost-casting crowns were ( 68.86 ± 5.41 ),( 58.86 ±6.10),(70.62 ±5.79),(69.90 ±6.00) μm.There were significant difference between two groups( P ＜0.05). Conclusions Co-Cr alloy full crown fabricated by wax-lost-casting method and SLM method provide acceptable marginal adaptation in clinic,and the marginal adaptation of SLM is better than that of wax-lost-casting method.