Abstract: Objective To investigate the relationship between C-reactive protein (CRP) + 1444C/T, CRP + 1059G/C polymorphisms and chronic periodontitis ( CP ) in a Han Chinese population. Methods Clinical periodontal parameters[ attachment loss( AL) probing depth(PD) and bleeding on probing(BOP) ] , and serum CRP levels were examined in CP patients (re = 126) and healthy subjects ( n = 113). Results The mean serum CRP level [ (1. 74 ± 1. 67) mg/L] was significantly higher in the CP group than in the control group [ (0. 57 ± 0. 39) mg/L] , P < 0. 001. In the control group, serum CRP levels were significantly lower in subjects with the CRP + 1059 GC and CC genotypes than those with the CRP +1059 GG genotype (P < 0.01). There was no significant difference between genotypes in the CP group. In CP and the control groups, serum CRP levels were significantly higher in subjects with the CRP + 1444 CT and TT genotypes compared to those with the CRP + 1444 CC genotype (P <0. 5). The percentage of CRP + 1059 C allele was 6. 7% (17/252) in the CP group and 4. 9% (11/226) in the control group. The percentage of CRP + 1444 T allele was 6. 3% (16/252) in the CP group and 5. 3% (12/226) in the control group (P > 0. 5). There was no significant difference between groups in both allele frequencies (P > 0. 5 ). The association of CRP + 1059G/C, CRP + 1444 C/T polymorphisms with CP was not found in a regression model ( P > 0. 5). Conclusions The presence of a CRP + 1059C-allele was associated with lower serum CRP levels and the presence of a CRP + 1444T-allele was associated with higher serum CRP levels. However, the data suggested that CRP + 1059G/C, CRP + 1444 C/T polymorphisms were not significantly associated with serum CRP levels of chronic periodontitis patients in ethnic Han Chinese.