Abstract： Objective To determine the level of high-density lipoprotein cholesterol (HDL-C), serum C-reactive protein (CRP) and inflammation cytokines and investigate the concentration between periodontal disease and coronary heart disease (CHD).Methods Sixty-six patients with CHD and chronic periodontitis[(C + P) group], forty-four with only CHD(C group), fifty-six with only chronic periodontitis (C group), and forty-three healthy controls(H group) were included in this study.The diagnosis of chronic periodontitis and CHD was based on accepted clinical criteria.Serum levels of HDL-C, CRP, IL-6, tumor necrosis factor (TNF)-a and IL-1β were tested in all patients and controls.Results The periodontal conditions of these four groups were significantly different (P<0.05).The clinical periodontal parameters[probing depth (PD), attachment loss (AL), and bleeding on probing (BOP)]in patients with (C + P) group, P group, C group and H group were[(4.55±0.85) mm, (3.78±0.34) mm, 69.6%],[(4.06±0.61) mm, (3.05±0.44) mm, 63.6%],[(1.85±0.67) mm, (1.26±0.39) mm, 20.5%],[(1.12±0.33) mm, (0.42±0.83) mm, 4.6%], respectively.The levels of HDL-C in H group, C group, P group and (C +P) group were(1.42±0.21) , (1.22±0.18), (1.24±0.21) and (1.04±0.22) mmol/L, respectively.T compare with other three groups, the level of HDL-C in (C+P) group is the lowest The levels of CRP, IL-6, TNF-α and IL-1β in (C+P) group were significantly higher than other groups (P<0.05).Conclusions HDL-C, CRP, IL-6, TNF-α and IL-1 β may be associated with the pathogenesis of periodontitis and CHD.There may be a relationship between the two diseases.