Abstract: Objective To investigate the incidence of radiation-induced maxillary malignancy after radiotherapy for head and neck cancer. Methods A total of 273 patients who suffered from osteoradionecrosis after radiotherapy for head and neck cancer were evaluated.Among them,6 patients were presented with carcinoma and sarcoma arising from maxillary area after radiotherapy.Results Radiationinduced maxillary cancers happened at a rate of 2.2% in the patients with osteoradionecrosis.There were no statistically significant difierences in age,sex and the time interval between the radiotherapy and the cancer occurence.Conclusions Radiation-induced malignancy after radiotherapy for head and neck cancer is mainly located in maxilla,presenting as squamous cell carcinoma or sarcoma of the maxillary sinus.