Detection of periodontal pathogens in coronary atherosclerotic plaques
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1002-0098.2008.01.003
- Key Word:
- 牙周炎;冠状动脉硬化;聚合酶链反应;Periodontitis;Coronary arteriosclerosis;Polymerase chain reaction
Abstract： Objective To explore the possible correlation between coronary heart disease and periodontitis.Methods Subgingival plaque samples and coronary atherosclerotic plaques were harvested from a total of 31 patients with periodontitis who scheduled for coronary artery bypass surgery. The bacteria DNA was obtained from subgingival plaque samples and coronary athemsclemtic plaques using the chelex-100 method. The extracted DNA Was examined using the polymerase chain reaction(PCR)technique. Results In coronary atherosclerotic plaques samples from the 31 patients,Porphyromona gingivalis(Pg,38.7%),Actinobacillus actinomycetemcomitans(Aa,0%),Fusobacterium nucleatum(Fn,22.6%),Prevotella intermedia(Pi,12.9%),Bacteroides forsythus(Bf,38.7%)were detected.The concordant presence of the same periodontal bacteria DNA in subgingival plaques and in coronary atherosclerotic plaques in the same patient was Pg 5(16.1%),Aa 0(0%),Pi 2(6.5%),Fn 4(12.9%)and Bf 8(25.8%).Conclusions The presence of periodontal bacteria DNA in coronary atherosclerotic plaques could indicate that periodontal pathogenic bacteria may play a role in the coronary heart disease process.
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