You Position: Home > Paper
Effect of bone morphogenetic proteins-2 on mandibular distraction osteogenesis in rabbits
( views:180, downloads:32 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1002-0098.2007.01.005
- Key Word:
- 骨形成蛋白2;基因疗法;牵张成骨
Abstract： 目的 探讨局部应用腺病毒介导的人骨形成蛋白2(adenovirus vectors containing human bone morphogenetic proteins 2,Ad-hBMP-2)对兔下颌骨牵张成骨的影响.方法 24只新西兰大白兔随机分为实验组(12只)和对照组(12只),并建立下颌骨双侧牵张成骨模型.经过5 d潜伏期后,以0.5 mm/12 h的速度牵张7 d.固定期第1天,在实验组骨牵张区注射0.2 ml滴度为1012pfu/L的Ad-hBMP2,对照组骨牵张区注射0.2 ml滴度为1012pfu/L的腺病毒介导的增强型绿色荧光蛋白.在固定期第7、14、28天对下颌骨牵张区进行骨密度及新生骨量比较.结果 Ad-hBMP-2治疗组牵张区骨密度及新生骨量明显高于对照组.结论 腺病毒介导的人骨形成蛋白2具有促进兔下颌牵张成骨的作用.
- [1]唐友盛,高益鸣,沈国芳,等.牵引成骨技术治疗小下颌畸形伴OSAS效果的初步报告[J].2000,(1).
- [2]王志国,胡静,邹淑娟,等.重组人骨形成蛋白-2促进兔下颌牵张成骨的研究[J].2004,(3).
- [3]王兴,林野,伊彪,等.牵引成骨技术在肿瘤术后下颌骨重建中的应用[J].2000,(6).
- [4]F S, Kaplan,E M, Shore.Bone morphogenetic proteins and C-FOS: early signals in endochondral bone formation.[J].1996,19.
- [5]Wozney JM,Li G,Simpson H,etc.Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis.[J].2002,20(4).
- [6]D.S Musgrave,P Bosch,S Ghivizzani,etc.Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone[J].1999,24(6).