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Susceptibility of Streptococcus mutans biofilm to antimicrobial agents
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1002-0098.2006.05.004
- Key Word:
- 链球菌,变异;生物膜;青霉素类;显微镜检查,共焦
Abstract： 目的用激光共聚焦扫描显微镜(CLSM)观察变形链球菌生物膜对抗菌剂的敏感性.方法在体外形成变形链球菌生物膜,用不同浓度青霉素分别作用于生物膜3 h.生物膜进行荧光染色,CLSM扫描观察.结果变形链球菌生物膜在青霉素浓度为2 500mg/L时作用3 h,未被完全杀死,随着药物浓度增加,生物膜对青霉素的抵抗力逐渐减弱.结论变形链球菌生物膜比浮游状态变形链球菌对青霉素具有更高的抵抗力,提示临床应该以新的思路来研究控制生物膜造成的感染.
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