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The relationship between a nucleotide substitution of S100A8 gene and aggressive periodontitis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1002-0098.2004.03.002
- Key Word:
- 牙周炎;多态性,单核苷酸;疾病遗传易感性;钙结合蛋白
Abstract： 目的筛选S100A8基因上游调控区的单核苷酸多态性位点,研究其与侵袭性牙周炎易感性的关系.方法提取30例侵袭性牙周炎患者和28名健康对照者的基因组DNA,行聚合酶链(PCR)反应及PCR产物直接测序.结果 S100A8翻译起始位点上游94 bp处存在一个A→G的替换,该替换位于顺式作用元件--γ-干扰素反应元件.所有具有等位基因G的个体均为杂合子.两组基因型和等位基因的分布差异均无统计学意义(23.2% vs 35.7%,11.7% vs 17.9%, P ＞0.05).结论初步研究显示,S100A8基因该位点的多态性与侵袭性牙周炎的易感性无明显相关性,但有必要扩大样本进一步研究.
- [1]周华,孟焕新,陈智滨.龈沟液蛋白质成分的电泳分析[J].1998,(2).
- [2]李霁,孟焕新,陈智滨.成人牙周炎治疗前后龈沟液蛋白质的电泳分析[J].1998,(5).
- [3]王戎机,孟焕新,陈智滨,等.龈沟液12 000蛋白质的N-末端氨基酸序列分析及其临床意义[J].2002,(4).
- [4]K F, Ross,M C, Herzberg.Calprotectin expression by gingival epithelial cells.[J].2001,69.
- [5]G, Hetland,G J, Talg?,M K, Fagerhol.Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro.[J].1998,51.
- [6]Geczy CL,Xu K.IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8.[J].2000,164(9).
- [7]Lackmann M,Cook DI,Poronnik P,etc.S100 protein CP-10 stimulates myeloid cell chemotaxis without activation.[J].1996,166(2).
- [8]Yui S,Tsurumaki K,Yamazaki M,etc.Growth-inhibitory and apoptosis-inducing activities of calprotectin derived from inflammatory exudate cells on normal fibroblasts: regulation by metal ions.[J].1997,61(1).
- [9]Passey RJ,Xu K,Geczy CL,etc.S100A8: emerging functions and regulation.[J].1999,66(4).
- [10]M, Lackmann,P, Rajasekariah,S E, Iismaa,etc.Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10.[J].1993,150.
- [11]Voganatsi A,Murthy RK,Miyasaki KT,etc.Mechanism of extracellular release of human neutrophil calprotectin complex.[J].2001,70(1).
- [12]Kinane DF,Teague PW,Wright AF,etc.Clinical and genetic analysis of a large North European Caucasian family affected by early-onset periodontitis.[J].2000,79(3).
- [13]K T, Miyasaki,A, Voganatsi,T, Huynh,etc.Calprotectin and lactoferrin levels in the gingival crevicular fluid of children.[J].1998,69.