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Relation between the expression of P-gp and GST-π in oral and maxillofacial squamous carcinoma and chemoresistance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1002-0098.2002.02.004
- Key Word:
- 癌,鳞状细胞;药物耐受性;P-糖蛋白;谷胱甘肽转移酶类
Abstract： 目的探讨P-糖蛋白(P-glycoprotein ,P-gp)和谷胱甘肽S转移酶π(glutathione transferase-π,GST-π)表达与化疗药物耐受性的关系.方法采用免疫组化过氧化物酶标记法检测口腔颌面部鳞癌和正常口腔粘膜组织样本中P-gp和GST-π的表达,结合MTT药敏检测结果分析.结果 P-gp和GST-π在恶性肿瘤中阳性表达率分别为57.1%和53.6%,在正常组织中未见表达;P-gp的表达与化疗药物总体耐受性有关;GST-π的表达与患者对顺铂耐受性有关.结论 P-gp和GST-π的阳性表达提示患者有化疗药物耐受倾向.P-gp和GST-π检测对判断口腔颌面部恶性肿瘤化疗耐药性有指导意义.
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