You Position: Home > Paper
An antimetastatic study of Arg-Asp (RD) on salivary adenoid cystic carcinoma in vivo
( views:287, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1002-0098.2002.02.003
- Key Word:
- 癌,腺样囊性;肿瘤转移;肽类
Abstract： 目的研究精氨酸-天冬氨酸(Arg-Asp,RD)抗涎腺腺样囊性癌实验性肺转移(salivary adenoid cystic carcinoma lung metastation, SACC-LM)的作用.方法观察不同剂量、不同时间RD灌胃对SACC-LM的影响.结果 30 mg/kg 和 120 mg/kg RD灌胃可抑制SACC-LM的形成;7.5 mg/ kg、30 mg/kg、 120 mg/kg RD灌胃均可延长SACC-LM鼠的生存期.结论 RD毒性小,可经口给药,具有抗SACC-LM的作用.
- [1]李盛琳,刘绣屏.人诞腺腺样囊性癌（SACC-83）细胞系的建立及其生物学特性[J].1990,025 (1).
- [2]Chieko Koike,Manabu Watanabe,Atsushi Isoai,etc.How platelet aggregation affects B16BL6 melanoma cell trafficking[J].1998,427(2).
- [3]K, Kouzi-Koliakos,G, Koliakos,C, Trontzos,etc.In vivo binding of the radioiodinated peptide YIGSR on B16 melanoma cells.[J].1996,16.
- [4]P C, Brooks,A M, Montgomery,M, Rosenfeld,etc.Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels.[J].1994,79.
- [5]C P, Carron,D M, Meyer,J A, Pegg,etc.A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.[J].1998,58.
- [6]MJ Humphries,K Olden,KM Yamada.A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells[J].1986,233 (4762).