A randomized controlled trial of multi-domain cognitive training for community older adults with mild cognitive impairment
- Author:
- No author available
- Journal Title:
- Chinese Journal of Psychiatry
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-7884.2012.04.011
- Key Word:
- 认知疗法;衰老;轻度认知障碍;Cognitive therapy;Aging;Mild cognitive impairment
Abstract： Objective To explore the effect of multi-domain cognitive training intervention amongst older adults with mild cognitive impairment (MCI).Methods One hundred and twenty participants were randomly allocated to intervention group (60 subjects) and control group (60 subjects).The intervention consists of twenty-four 60-minute sessions delivered twice per week over a period of 12 weeks.Outcomes were assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS),Visual Reasoning Test,Color Word Stroop Test (CWST) and Trail Making Test (TMT),and collected at baseline and immediate after intervention.Results (1) No significant group difference was found except attention index of the RBANS (intervention group 81.3±15.5,control group 74.3±12.1,t=-2.37,P=0.02) at baseline.(2) Most outcomes showed significant group differences after intervention,including RBANS total score (intervention group 86.4±12.6,control group 78.6±9.3,t=3.07,P=0.00),immediate memory (intervention group 83.4±14.1,control group 74.6±11.5,t=3.03,P=0.00),delayed memory (intervention group 91.8±17.4,control group 83.7±13.0,t =2.32,P =0.02),and visuo-spatial/constructional (intervention group 95.7±14.3,control group 89.1±12.9,t=2.16,P=0.03) indices of RBANS,the visual reasoning test (intervention group 5.2±1.9,control group 3.9±1.9,t=3.11,P=0.00) and completing time of TMT A (intervention group 110.0±44.4,control group 130.5±45.1,t=-2.07,P=0.04).Conclusions Multi-domain cognitive training intervention could effectively improve or maintain cognition of community older adults with MCI.
- [1]冯威,李春波,陈优,等.社区健康老人综合认知训练1年随访观察[J].2009,(3).
- [2]冯威,李春波,吴文源,等.综合认知训练对社区健康老人认知功能的影响[J].2008,(3).
- [3]薛志强,冯威,李春波,等.对社区老人认知功能干预的近期效果[J].2007,(5).
- [4]薛海波,肖世富,李春波,等.老年成套神经心理测验与痴呆[J].2003,(3).
- [5]Gauthier S,Reisberg B,Zaudig M,etc.Mild cognitive impairment.[J].2006,367(9518).
- [6]Riedel Heller SG,Briel S,Luppa M,etc.Incidence of mild cognitive impairment: a systematic review.[J].2010,29(2).
- [7]Yan, Cheng,Wenyuan, Wu,Jiaqi, Wang,etc.Reliability and validity of the Repeatable Battery for the Assessment of Neuropsychological Status in community-dwelling elderly.[J].2011,7(5).
- [8]Angela K, Troyer,Kelly J, Murphy,Nicole D, Anderson,etc.Changing everyday memory behaviour in amnestic mild cognitive impairment: a randomised controlled trial.[J].2008,18(1).
- [9]Bianchetti A,Fedi V,Guerreschi M,etc.Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study.[J].2007,44(Suppl.1).
- [10]Yan, Cheng,Wenyuan, Wu,Wei, Feng,etc.The effects of multi-domain versus single-domain cognitive training in non-demented older people: a randomized controlled trial.[J].2012,10.
- [11]Gates, N.,Valenzuela, M..Cognitive Exercise and Its Role in Cognitive Function in Older Adults[J].2010,12(1).
- [12]C, Randolph,M C, Tierney,E, Mohr,etc.The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity.[J].1998,20(3).
- [13]Trabucchi M,Cipriani G,Bianchetti A.Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment.[J].2006,43(3).
- [14]Ivnik RJ,Tangalos EG,Petersen RC,etc.Mild cognitive impairment: clinical characterization and outcome.[J].1999,56(3).
- [15]Van der Elst, W.,Van Boxtel, M.P.J.,Van Breukelen, G.J.P.,etc.Detecting the Significance of Changes in Performance on the Stroop Color-Word Test, Rey's Verbal Learning Test, and the Letter Digit Substitution Test: The Regression-Based Change Approach[J].2008,14(1).
- [16]肖世富,徐巍,姚培芬.世界卫生组织老年认知功能评价成套神经心理测验的临床初步应用[J].1999,(4).