Brachial-ankle pulse wave velocity based-prediction of hypertension in middle-aged prehypertensive men

( views:153, downloads:0 )
WANG Zheng(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
HAN Fei-zhou(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
ZHAO Peng(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
ZHANG Yu(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
YANG Jian-tao(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
LING Hong-ling(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
Journal Title:
Chinese Journal of Health Management
Volume 06, Issue 04, 2012
Key Word:
Prehypertension;Hypertension;Brachial-ankle pulse wave velocity

Abstract: Objective To investigate the value of brachial-ankle pulse wave velocity (baPWV) in the prediction of hypertension in middle-aged men with prehypertension.Methods A total of 2580 middle-aged (35 to 55 years old ) prehypertensive individuals who underwent health check-up during September 2006 and December 2007 in our hospital were recruited for this prospective cohort study.After a 4-year follow-up,2451subjects entered final analysis.Logistic regression analysis was used to assess the value of baPWV in the prediction of hypertension.Results (1) Two hundred and eight subjects (8.5% )developed hypertension after 4-year follow-up study.( 2 ) At baseline,no significant differences of family history of hypertension,heart rate and total cholesterol were found between normotensive and hypertensive subjects (P >0.05 ).(3) Logistic regression analysis showed that in age-adjusted model (Model1),the odds ratio (OR) and 95% confidence interval (CI) of baPWV (140 cm/s) was 2.20 (1.78 to 2.62 )( P <0.01) ; while in multi-factor adjusted model ( Model 3 ),OR and 95c%c CI of baPWV was I.49 (1.15 to 1.73) (P < 0.01).(4) Subjects were stratified by quartiles of baPWV at baseline.OR and 95% CI of hypertension in those of highest quartile was higher than those of lowest quartile ( Model1:OR =10.9,95%CI 5.1-22.7,P<0.01; Model 3:0R=2.6,95%CI1.2 -6.1,P<0.05).Conclusion baPWV could be an independent predictor of hypertension among prehypertensive populations.

  • [1]中国高血压防治指南修订委员会.中国高血压防治指南2010.中华心血管病杂志,2011,39:579-616.
  • [2]刘冰,李卫,胡泊.中国35 ~ 45岁人群高血压前期检出率及影响因素分析.中华高血压杂志,2010,18:187-192.
  • [3]Julius S,Nesbitt SD,Egan BM,et al.Feasibility of treating prehypertension with an angiotensin-receptor blocker.N Engl J Med,2006,354:1685-1697.
  • [4]Najjar SS,Scuteri A,Shetty V,et al.Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.J Am Coil Cardiol,2008,51:1377-1383.
  • [5] Yamashina A, Tomiyama H, Takeda K, et al.Validity,reproducibility,and clinical significance of noninvasive brachialankle pulse wave velocity measurement.Hypertens Res,2002,25:359-364.
  • [6] Park KH,Park WJ,Kim MK,et al.Noninvasive brachial-ankle pulse wave velocity in hypertensive patients with left ventricular hypertrophy.Am J Hypertens,2010,23:269-274.
  • [7]Tomiyama H,Koji Y,Yambe M,et al.Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome.Cinc J,2005,69:815-822.
  • [8]Takase H,Dohi Y,Toriyana T,et al.Brachial-ankle pulse wave velocity predicts increase in blood pressure and onset of hypertension.Am J Hypertens,2011,24:667-673.
  • [9] Satoh H,Saijo Y,Kishi R,et al.Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects.Environ Health Prey Med,2011,16:217-223.
  • [10]赵小兰,陈虹,李永红,等.重庆部分公务员三年62169例健康体检状况评估与分析.中华健康管理学杂志,2012,6:85-88.
  • [11] Munakata M,Ito N,Nunokawa T.Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients.Am J Hypertens,2003,16:653-657.
  • [12]Stefanadis C,Demellis J,Vlachopoulos C,et al.Aortic function in arterial hypertension determined by pressure-diameter relation:effects of diltiazem.Circulation,1997,96:1853-1858.
  • [13]Wilkinson IB,Franklin SS,Cockcroft JR.Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology.Hypertension,2004,44:112-116.
  • [14] Kameyama H,Takeda K,Kusaba T,et al.Augmentation of pulse wave velocity precedes vascular structural changes of the aorta in rats treated with N (omega)-nitro-L-arginine methyl ester.Hypertens Res,2005,28:439-445.
  • [15]陆昀,沈振海,李红卫,等.生活方式干预对代谢综合征患者动脉血管早期病变检测指标的影响.中华健康管理学杂志,2012,6:45-49.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615