Brachial-ankle pulse wave velocity based-prediction of hypertension in middle-aged prehypertensive men

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Author:
WANG Zheng(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
HAN Fei-zhou(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
ZHAO Peng(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
ZHANG Yu(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
YANG Jian-tao(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
LING Hong-ling(Department of Sanatorium of People's Liberation Army, Hangzhou 310007, China)
Journal Title:
Chinese Journal of Health Management
Issue:
Volume 06, Issue 04, 2012
DOI:
10.3760/cma.j.issn.1674-0815.2012.04.003
Key Word:
Prehypertension;Hypertension;Brachial-ankle pulse wave velocity

Abstract: Objective To investigate the value of brachial-ankle pulse wave velocity (baPWV) in the prediction of hypertension in middle-aged men with prehypertension.Methods A total of 2580 middle-aged (35 to 55 years old ) prehypertensive individuals who underwent health check-up during September 2006 and December 2007 in our hospital were recruited for this prospective cohort study.After a 4-year follow-up,2451subjects entered final analysis.Logistic regression analysis was used to assess the value of baPWV in the prediction of hypertension.Results (1) Two hundred and eight subjects (8.5% )developed hypertension after 4-year follow-up study.( 2 ) At baseline,no significant differences of family history of hypertension,heart rate and total cholesterol were found between normotensive and hypertensive subjects (P >0.05 ).(3) Logistic regression analysis showed that in age-adjusted model (Model1),the odds ratio (OR) and 95% confidence interval (CI) of baPWV (140 cm/s) was 2.20 (1.78 to 2.62 )( P <0.01) ; while in multi-factor adjusted model ( Model 3 ),OR and 95c%c CI of baPWV was I.49 (1.15 to 1.73) (P < 0.01).(4) Subjects were stratified by quartiles of baPWV at baseline.OR and 95% CI of hypertension in those of highest quartile was higher than those of lowest quartile ( Model1:OR =10.9,95%CI 5.1-22.7,P<0.01; Model 3:0R=2.6,95%CI1.2 -6.1,P<0.05).Conclusion baPWV could be an independent predictor of hypertension among prehypertensive populations.

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