Glycated haemoglobin and identification of metabolic syndrome in non-diabetics

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Author:
LIU An-nan(Center of Health Assessment, Beijing Hospital, Beijing 100730,China)
ZHU Ling()
SUN Ming-xiao()
WAN Gang()
Journal Title:
Chinese Journal of Health Management
Issue:
Volume 06, Issue 01, 2012
DOI:
10.3760/cma.j.issn.1674-0815.2012.01.007
Key Word:
Metabolic syndrome X;Hameglobin A, glycosylated;Blood glucose

Abstract: Objective To examine the sensitivity and specificity of glycated haemoglobin A1c (HbA1c) in predicting metabolic syndrome (MS) and its association with cardiovascular risk factors.Methods In 6292 adults (median age 45 years) who participated in a medical check-up program,analysis of distribution of HbA1c and its association with various cardiovascular risk factors was performed. The ability of HbA1 c to predict MS was evaluated.Anthropometric measurements were made and fasting plasma glucose,lipid profiles and HbA1c were tested. Results The prevalence of MS was 11.24%.Cardiovascular risk factors were significantly increased as the serum level of HbA1c increased. HbA1c of 5.8% predicted the presence of MS.Females showed the same cut-off of HbA1c for the prediction of MS with males ( the area under the curve of the females was higher than that of the males ). Conclusion HbA1c was increased as cardiovascular risk factors increased and HbA1c of 5.8% may predict the presence of MS.HbA1c might be a predictive measure of MS and cardiovascular diseases in adults.

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