Lifestyle intervention improves oxidant stress in overweight or obese adolescents

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Author:
ZHANG Xian-bo(The Fifth Clinical Hospital, Peking University Health Science Center, Beijing 100730, China)
HUANG Xiu-qing()
SUN Ming-xiao()
YAN Yi()
LI Bo-wen()
ZHONG Wei-juan()
CHEN Jun-fei()
WANG Lu()
XIE Min-hao()
Journal Title:
Chinese Journal of Health Management
Issue:
Volume 05, Issue 06, 2011
DOI:
10.3760/cma.j.issn.1674-0815.2011.06.007
Key Word:
Diet;Exercises;Overweight

Abstract: Objective To explore the effects of diet and/or exercise intervention on oxidative stress of overweight or obese adolescents.Methods Thirty-one adolescents with normal body weight(normal control group)and 93 overweight or obese adolescents(average age(13.6 ±0.7)years; body mass index (BMI)22.4 to 34.1 kg/m2)were enrolled in this study.The overweight or obese participants were then randomly assigned to the diet group(group A),exercise group(group B),diet plus exercise group(group C),and non-intervention group(group D).Individualized caloric intake was carried out.One-hour afterschool exercise was performed once per day,4 days per week for 10 weeks.Changes of anthropometry,body composition,and metabolic biomarkers were determined.Results Compared to the normal control group,serum levels of fasting glucose,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and malondialdehyde(M DA)of the in overweight group were significant increased(all P < 0.05),although the level of SOD was significant decreased(P < 0.05).Serum MDA level was positively correlated with bodyweight,BMI,TC,and LDL-C(R values were 0.209,0.228,0.274,and 0.263,respectively ; all P <0.05),and serum SOD level was negatively correlated with bodyweight and BMI(R values were-0.334 and-0.362,respectively ; both P < 0.05).Group A,B and C showed a significant decrease in BMI,waist circumference and body fat after the intervention(all P < 0.05).The level of MDA was significantly decreased after the intervention in group A and B(both P < 0.05); the levels of TC and LDL-C were significantly decreased in group B and C(both P < 0.05).Conclusion:Oxidative stress could have existed in overweight adolescents even when their serum glucose and lipid profiles are at a normal level.Ten-week diet and/or exercise intervention may contribute to improved body weight control,lipid metabolism,and oxidative stress response in this population.

  • [1]Ostrow V,Wu S,Aguilar A,et al.Association between oxidative stress and masked hypertension in a multi-ethnic population of obese children and adolescents.J Pediatr,2011,158:628-633.
  • [2]Puchau B,Ochoa MC,Zulet MA,et al.Dietary total antioxidant capacity and obesity in children and adolescents.Int J Food Sci Nutr,2010,61:713-721.
  • [3]Xu YQ,Ji CY.Cooperative study on childhood obesity:Working Group on Obesity in China.Report on Childhood Obesity in China (7).Comparison of NCHS and WGOC.Biomed Environ Sci,2008,21:271-279.
  • [4]Ji CY,Working Group on Obesity in China.Report on childhood obesity in China(1)-body mass index reference for screening overweight and obesity in Chinese school-age children.Biomed Environ Sci,2005,18:390-400.
  • [5]Sun MX,Huang XQ,Yan Y,et al.One-hour after-school exercise ameliorates central adiposity and lipids in overweight Chinese adolescents:a randomized controlled trial.Chin Med J,2011,124:323-329.
  • [6]Limbers CA,Turner EA,Varni JW.Promoting healthy lifestyles:Behavior modification and motivational interviewing in the treatment of childhood obesity.J Clin Lipido1,2008,2:169-178.
  • [7]沈兴平,邹森彪,吴豪杰,等.肥胖患者氧化应激和脂肪细胞因子变化.细胞与分子免疫学杂志,2008,24:721-723.
  • [8]肖伟强,肖志强,李艳萍,等.肥胖患儿体内抗氧化剂抗氧化酶和丙二醛的检测及分析.中国实用儿科杂志,2006,21:182-184.
  • [9]Codoner-Franch P,Pons-Morales S,Boix-García L,et al.Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitus.Pediatr Diabetes,2010,11:251-257.
  • [10]Pratt KJ,Lamson AL,Collier DN,et al.Camp Golden Treasures:a multidisciptinary weight-loss and a healthy lifestyle camp for adolescent girls.Faro Syst Health,2009,27:116-124.
  • [11]杨正雄,王卉呈,冯雅靖,等.社区超重与肥胖人群体重管理效果的研究.中华健康管理学杂志,2010,4:149-152.
  • [12]Codoner-Franch P,Valls-Bellés V,Arilla-Codoner A,et al.Oxidant mechanisms in childhood obesity:the link between inflammation and oxidative stress.Transl Res,2011,158:369-384.
  • [13]Del Rio D,Stewart AJ,Pellegrini N.A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress.Nutr Metab Cardiovasc Dis,2005,15:316-328.
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