Effect of weight loss on metabolic parameters in over-weight or obesity patients combined with impaired glucose tolerance

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Author:
LIU Yan-jun(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
XIAO Ting(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
ZHU Ping(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
CHENG Yu-xia(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
YANG Xiao-ping(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
CAO Dong-ping(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
XU Zhang-rong(Department of Endocrinology, the 306 Hospital of PLA, Beijing 100101, China)
Journal Title:
CHINESE JOURNAL OF HEALTH MANAGEMENT
Issue:
Volume 04, Issue 03, 2010
DOI:
10.3760/cma.j.issn.1674-0815.2010.03.006
Key Word:
Overweight;Obesity;Metabolism

Abstract: Objective To evaluate the effective of weight loss on blood glucose,lipid profile,and blood pressure in over-weight or obesity patients combined with impaired glucose tolerance(IGT).Methods Body weight of 91 over-weight or obesity IGT patients were managed by doctors and nurses.Body weight,waist circumference,blood glucose,lipid profile,blood pressure and liver function of the patients were compared at 3 months with baseline.Results After 3 months' intervention,the levels of body weight,waist circumference,fasting plasma glucose,postprandial glucose,systolic blood pressure,diastolic blood pressure,and glutamie oxalacetie transaminase (COT),instead of triglyeeride and hish-density lipoprotein cholesterol (HDL-C),were significantly reduced.Over weight or obesity IGT patients saw a 1.8 and 2.3 kg body weight loss,respectively.Decreased plasma glucose and blood pressure were found both in the over-weight group and in the obesity groups,but decreased waist circumference and GOT were found only in the over-weight patients.Conclusions Body-weight control may improve the blood glucose,blood pressure,central obesity,or fatty liver in over weight or obesity IGT patients.For those obesity patients,longer and stronger body weight control should be needed.

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