Value of dipyridamole stress 201Tl myocardial SPECT in detecting dysfunction of coronary microcirculation
- Author:
- No author available
- Journal Title:
- Chinese Journal of Nuclear Medicine and Molecular Imaging
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.2095-2848.2012.05.010
- Key Word:
- 微血管性心绞痛;体层摄影术,发射型计算机,单光子;双嘧达莫;铊放射性同位素;Microvascular angina;Tomography,emission-computed,single-photon;Dipyridamole;Thallium radioisotopes
Abstract： Objective To evaluate the value of dipyridamole stress 210Tl myocardial SPECT in detecting dysfunction of coronary microcirculation.Methods Forty-eight patients diagnosed with cardiac syndrome X underwent dipyridamole stress 210Tl myocardial SPECT.Dipyridamole (0.56 mg/kg) was intravenously injected over 4 min followed by 201Tl (111 MBq) injection at 2 min after dipyridamole administration.Image was acquired at 10 min and 240 min post-injection and co-analyzed by over two experienced doctors in nuclear medicine after three-dimensional reconstruction.The patients with " reverse redistribution" underwent repeated dipyridamole stress 201Tl SPECT after medical therapy for 2 weeks.The clinical symptoms and results of the treadmill exercise test pre-and post-therapy were compared.Results Fortytwo patients (42/48,87.50％) showed segmental defects:"reverse redistribution" on delayed (240 min)201Tl images.After medical treatment,36 cases of the 42 "reverse redistribution" patients had improvement in both clinical symptoms and treadmill exercise test.Post-treatment 201Tl imaging showed improvement in 45/49 (91.84％) defect segments.Six of the 42 patients had no improvement in clinical symptoms and/or treadmill exercise test.Post-treatment 201Tl imaging showed no improvement in all the 7 defect segments on the first scan.Conclusion Dipyridamole stress 201Tl myocardial SPECT may be valuable in evaluation of impaired coronary microcirculation associated with cardiac syndrome X.
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