Effect of comprehensive HBO therapy on acute cerebral infarction and study of best therapeutic time window

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Author:
ZHOU Xuan(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
HAN Xin-jian(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
CHEN Peng(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
WANG Yu-li(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
HAN Dong(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
WEI Wei(Central Hospital of Zaozhuang Mining Group, LTD. CO. Zaozhuang 277011, China)
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
Volume 19, Issue 04, 2012
DOI:
10.3760/cma.j.issn.1009-6906.2012.04.005
Key Word:
Hyperbaric oxygen;Acute cerebral infarction;Time window

Abstract: Objective To compare the curative effects of hyperbaric oxygen(HBO) and conventional therapy on acute cerebral infarction (ACI),and to study the best therapeutic time window of HBO therapy on ACI.Methods One hundred and ninety-six patients with ACI admitted into the hospital from June 2006 to December 2010 were divided into the HBO group ( n =98) and the control group ( n =98 ).The HBO group was subdivided into the < 6 h therapy group,the 6-48 h therapy group and the > 48 h therapy group,in accordance with the duration of HBO exposure.In addition to HBO therapy,the HBO group also received conventional therapy.The patients received HBO therapy once a day,10 days as one therapeutic course,totaling 3 courses.The time used for compression and decompression was 60 min.In the chamber,the patients were exposed to a pressure of 0.25 MPa for a duration of 120 min and breathed pure oxygen with masks for 60 min (30 minutes of oxygen breathing,at a time,and a 10 min interval).All the patients were assessed with National Institute of Health Stroke Scale ( NIHSS ) and Barthel Index (BI) both before treatment and after termination of the treatment courses.Then,they were compared with those ACI patients (the control group)receiving conventional therapy.Results After treatment,total effective rates for each HBO therapy sub-group were 97.3%,90.0% and 80.7%,which were significantly higher than those of the conventional therapy subgroups with effective rates of 85.7%,77.1% and 57.1% respectively (P <~ 01 ).In the HBO group,the effective rate for the < 6 h sub-group was significantly higher than those of the 6-48 h and the > 48 h subgroups (P < 0.05 ).NIHSS scores in each HBO sub-group were significantly lower than those of the conventional therapy group,and BI cores were significantly higher than those of all the sub-groups in the conventional group (P < 0.01 ).In the HBO group,the score for the ≤6 h sub-group were obviously superior to those of the 6-48 h and the ≥48 h sub-groups ( P < 0.05 ).Conclusions HBO therapy could produce a significant result for the treatment of ACI and the best therapeutic time was within 6 hours after the onset of ACI.

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