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Effects of HBO on the content of serum S-100B protein in patients with acute cerebral infarction

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Author:
No author available
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
6
DOI:
10.3760/cma.j.issn.1009-6906.2011.06.012
Key Word:
急性脑梗死;S-100B蛋白;高压氧;Acute cerebral infarction;S-100B protein;Hyperbaric oxygen

Abstract: Objective To investigate the effects of HBO on the content ot resum S-100tB protein in patients with acute cerebral infarction and also to evaluate the effect of HBO therapy.Methods One hundred and twenty cases of acute cerebral infarction were scanned with MRI/MRA to measure the size of cerebral infarction.The patients were divided into the HBO group(n =56) and the control group(n =64),depending on the method of the treatment they received.The changes of the content of serum S-100B protein for the patients of both groups were detected with ELISA at 24,48,72,96 h respectively after admission imto hosfoital.Results The expression of serum S-100B protein reached peak at 72 h after the patients imto hospital.The content of S-100B protein was directly correlated with the size of cerebral infarction (P < 0.01 or P < 0.05 ).The decrease of the contents of S-100B protein[small infarction: (0.71 ± 0.25 ) μg/L,middle infarction:(1.22 ± 0.37)μg/L]in the HBO group was more significant,when compared with those in the control group [ small infarction: ( 1.26 ± 0.36 ) μg/L,middle infarction: ( 2.02 ± 0.72 ) μg/L ],with statistical significance (P <0.01 or P <0.05 ).Conclusions The level of serum S-100B protein was closely correlated with the size of cerebral infarction,which might be a good precursor for the prediction of progressive cerebral stroke.Early clinical HBO therapy could decrease S-100B and had some effect on the treatment of patients with acute cerebral infarction.

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