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Protective effect of macrophage inflammatory protein-2 antibody in lung tissue of pulmonary oxygen toxicity in mice

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
Issue:
3
DOI:
10.3760/cma.j.issn.1009-6906.2010.03.003
Key Word:
高压氧;肺型氧中毒;巨噬细胞炎症蛋白-2抗体;Hyperbaric oxygen;Pulmonary oxygen toxicity;Macrophage inflammatory protein-2 antibody

Abstract: Objective To observe the effects of MIP-2 antibody on the inflammation in lung tissue of pulmonary oxygen toxicity in mice.Methods The pulmonary oxygen toxicity model were duplicated by breathing hyperbaric oxygen,and 40 mice were randomly divided into 5 groups:control group.0.2 MPa-224 min group,0.2 MPa-289 min group,normal O2 group,and antibody group.Mice in the control group breathed normal air,the normal O2 group breathed N2-O2 gas mixture,in which O2 partial pressure was same to that in the atmosphere.The antibody group breathed MIP-2 antibody aerosol.The expression of MIP-2 in the lung was measured by IHC.Results The MIP-2 abundance of HBO treated groups was significantly higher than that of the control group (P<0.05),whereas the expression of MIP-2 of the normal O2 group was not significantly higher than that of the control group (P>0.05).MIP-2 antibody may alleviate inflammation lesion of pulmonary oxygen toxicity in mice.Conclusions Pulmonary oxygen toxicity might elevate expression of MIP-2,and MIP-2 antibody alleviate inflammation lesion of pulmonary oxygen toxicity in mice.

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