You Position: Home > Paper

Pathological changes in tissues induced by serious experimental decompression sickess in rabbits

( views:212, downloads:28 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
Issue:
6
DOI:
10.3760/cma.j.issn.1009-6906.2009.06.001
Key Word:
快速减压;减压病;急性脑水肿;病理;Rapid decompression;Decompression sickness;Acute cerebral edema;Pathology

Abstract: Objective To investigate pathological changes in tissues induced by serious experimental decompression sickness (DCS) in rabbits. Methods Serious decompression sickness animal model was developed by using New Zealand rabbits. The animals were placed in a dry chamber, pressurized with air to 0.7 MPa(7ATA)and stayed at the said pressure for 60 minutes, then, surfaced by rapid decompression (in 5 minutes) to induce serious DCS. Survival rate and signs of DCS were closely monitored both before compression and after decompression. Organ tissues (heart, liver, lungs, kidney and brain) were harvested 15 min, 1 h,24 h after decompression for histologic studies. Results Results showed that pathological changes in the lungs,liver and brain were more obvious, while changes in the heart were less serious. Rabbits that died 15 minutes after decompression mainly had edema in brain tissues, animals that had DCS but survived for 1 hour chiefly displayed pathological changes in heart tissues. Twenty-four hours after decompression, histopathological examination indicated that edema and hemorrhage in various tissues decreased, with inflammatory infiltration and microthrombosis as chief manifestations. Conclusions Acute cerebral edema was the main reason causing the dead of animals with serious decompression sickness. The first hour after rapid decompression seemed to be the critical time for salvaging the lives of those with serious decompression sickness. Pathological changes in the circulation system were chief manifestations during this period. Inflammatory infiltration and microthrombosis were chief manifestations 24 hours after decompression.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn