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Effect of early hyperbaric oxygen treatment on prevention of disorder of coagulation-fibrinolysis systems in rabbits with steroid-induced avascular necrosis offemoral head

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
Issue:
3
DOI:
10.3760/cma.j.issn.1009-6906.2008.03.006
Key Word:
高压氧;激素性股骨头坏死;抗凝血酶Ⅲ;血栓调节蛋白;组织型纤溶酶原激活物;纤溶酶原激活物抑制剂-1;Hyperbaric oxygen;Steroid-induced avascular necrosis of femoral head;Antithrombin-Ⅲ;Thrombomodulin;Tissue-type plasminogen activator;Plasminogen activator inhibitor-1

Abstract: Objective To observe the changes of contents of indexes of coagulation-fibrinolysis systems of steroid-induced avascular necrosis of femoral head ( SANFH) in rabbits before and after hyperbaric oxygen (HBO) treatment and to investigate the mechanism of action of early HBO treatment on SANFH . Methods Animal models of steroid-induced avascular necrosis of femoral head were established, then contents of antithrombin-Ⅲ(AT-Ⅲ), thrombomodulin(TM) , tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 ( PAI-1) were measured in each group respectively. Results The content of AT-Ⅲ in HBO group was significantly higher than that in model group at four and six weeks( P <0.01). The content of TM in HBO group was significantly lower than that in model group at one week(P <0. 05), whereas higher at four weeks (P < 0.05). At two weeks, the content of tPA in HBO group was significantly higher than that in model group(P<0. 05) , whereas that of PAI-1 lower (P < 0. 05). Conclusions Early HBO therapy can relieve endothelial cell injury of blood vessel, promote synthesize and discharge of anticoagulative factor and accelerate dissolution of fibrin, which improve hypercoagulability state of model animals of SANFH.

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