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Inhibitory action of terbutaline on inflammatory reaction of lung tissue in rabbits with lung edema induced by seawater drowning
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-6906.2007.06.005
- Key Word:
- 淹溺;海水;炎症反应;特布他林
Abstract： 目的 探讨特布他林对海水淹溺型肺水肿兔肺组织炎症反应的影响.方法 36只机械通气的麻醉新西兰兔随机分成正常组(N组)、对照组(C组)和特布他林治疗组(T组).C组和T组经颈动脉注入4 ml/kg的配方海水,20 min后C组经颈动脉注入2 ml生理盐水,而T组则注入0.15 mg/kg特布他林,N组除未注入配方海水外,其余处理同C组.观察肺泡灌洗液(BALF)中TNF-α计量和中性粒细胞计数,取部分右下肺常规病理学检查,并分别用RT-PCR和ELISA检测肺组织中TNF-α、IL-1β和IL-8的mRNA表达及蛋白含量.结果 病理学观察显示C组的肺组织内有大量的炎性细胞浸润,肺泡隔断裂、肺泡破裂、相互融合、肺泡大量萎陷,肺泡内有出血及透明膜形成.T组的上述改变轻于C组.T组肺组织内TNF-α、IL-1β和IL-8的mRNA表达及蛋白含量均显著低于C组(P＜0.05),BALF中TNF-α和中性粒细胞计数减少.结论 特布他林可以抑制海水淹溺型肺水肿兔肺组织的TNF-α、IL-1β和IL-8,从而减轻肺组织炎症反应.
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