You Position: Home > Paper
Research on noise exposure project for greening susceptible animal to noise-induced hearing loss
( views:205, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-6906.2007.03.005
- Key Word:
- 噪声;暂时性听阈偏移;脑干诱发电位;噪声听觉损伤
Abstract： 目的 筛选一种噪声暴露方案,以便较好地区分听觉损伤易感豚鼠和不易感豚鼠.利用该噪声暴露方案建立噪声听觉损伤模型,在此基础上确定易感与不易感豚鼠,为进一步开展易感性相关基因研究提供便利.方法 60只雄性健康豚鼠(体重280～320 g)随机平均分为3组,分别为A方案组(105 dBA噪声暴露)、B方案组(110 dBA噪声暴露)、C方案组(115 dBA噪声暴露).评价各方案区分易感与不易感豚鼠的效能,确定最佳方案.利用该方案建立噪声听觉损伤模型,利用百分位数的方法确定噪声听觉损伤易感与不易感豚鼠.结果 B方案组和C方案组豚鼠TTS分布的离散程度无明显差异,但均大于A方案组.模型建立中,数据成左偏态分布,利用百分位数确定了易感与不易感豚鼠.结论 B方案更适合于建立筛选用的豚鼠噪声听觉损伤易感模型.
- [1]司峻峰,宁新宝,薛方.听觉诱发电位检测及分析[J].2003,(1).
- [2]张雪松,贾琳琳,张雪岩,等.全身麻醉对听觉脑干反应测试结果的影响[J].2004,006 (4).
- [3]R R, Davis,J K, Newlander,X, Ling,etc.Genetic basis for susceptibility to noise-induced hearing loss in mice.[J].2001,155(1-2).
- [4]Jing-qiao, Lu,Yi-ming, Zhao.[Progress on the study of genes associated with individual susceptibility to noise-induced hearing loss].[J].2003,37(4).
- [5]孙振球主编.医学统计学[M].2002.
- [6]Gary W, Harding,Barbara A, Bohne,Jeremy D, Vos.The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noise.[J].2005,204(1-2).