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The inhibitory effects of dexamethasone on inflammatory responses in the lung tissue of rabbits with acute lung injury induced by seawater drowning
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2006.04.003
- Key Word:
- 淹溺;海水;急性肺损伤;炎症反应
Abstract： 目的 了解地塞米松对海水淹溺性肺损伤兔肺组织炎症反应的影响.方法 机械通气的麻醉新西兰兔随机分成对照组(CG)和地塞米松治疗组(DG),每组12只.CG兔的气管内灌注4 ml/kg体重海水,DG兔在CG的基础上静注1 mg/kg地塞米松.取部分右下肺行常规病理学检查.分别用RT-PCR和ELISA检测肺组织中TNF-α、IL-1β和IL-8的mRNA表达及蛋白含量.结果 病理学观察显示CG的肺组织内有大量的炎性细胞浸润,肺泡腔内有出血及透明膜形成.DG的上述改变轻于CG.DG肺组织内TNF-α、IL-1β和IL-8的mRNA表达及蛋白含量显著低于CG(P＜0.05).结论 地塞米松治疗可抑制海水淹溺性肺损伤兔肺组织TNF-α、IL-1β和IL-8的表达,减轻肺组织内炎症反应.
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