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Experimental study of open fractures with seawater immersion
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-6906.2006.03.004
- Key Word:
- 开放性骨折;海水;病理;感染;放射诊断
Abstract： 目的观察海水浸泡开放骨折的伤口感染,组织学、影像学变化,了解海水浸泡开放骨折的伤情特点.方法新西兰大白兔75只,随机分为普通开放骨折组(对照组)27只和海水浸泡开放骨折组(实验组)48只.造成桡骨横行1.5 mm缺损完全开放骨折,普通开放骨折伤组旷置3h,海水浸泡开放骨折伤组海水浸泡伤口3 h,之后依次缝合伤口.于第1、3、7、14、21、28、45天处死动物.观察海水浸泡开放骨折伤在骨折愈合中不同时间的病理过程、影像学特点及伤口感染特点.结果(1)对照组肢体感染率11.9%,实验组肢体感染率31.0%(两组相比P＜0.05).(2)海水浸泡开放骨折伤骨痂形成延迟,骨折后第28天,对照组断端间骨痂为骨性骨痂者8例,为软骨骨痂者4例;实验组断端间骨痂为骨性骨痂者6例,为软骨骨痂者14例.(3)骨折后第28天,断端间骨痂灰度值对照组为181.00±8.09,实验组为147.10±5.80;骨折后第45天,断端间骨痂灰度值对照组为217.50±7.50,实验组为243.00±8.26(两组相比P＜0.05).结论(1)海水浸泡使开放骨折感染率增高;(2)海水浸泡使骨折愈合满意率下降,骨痂形成不良率增高,骨折愈合过程延迟.
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