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Changes of activity of thrombocyte in mice after acute carbon monoxide poisoning and the effect of hyperbaric oxygen on them
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-6906.2005.02.003
- Key Word:
- 急性一氧化碳中毒;高压氧;血小板活性;血小板平均相对体积;血小板 CD 61
Abstract： 目的观察急性一氧化碳中毒(ACOP)大鼠血小板活性的变化及其高压氧(HBO)暴露的影响.方法将实验动物Wistar大鼠共128只随机分成正常对照组(NC组)、一氧化碳中毒组(COP组)、一氧化碳中毒+高气压组(HPT组)及一氧化碳中毒+高压氧组(HBO组).测定COP后1,5,10,15,20 d大鼠血小板平均相对体积及血小板CD 61的动态变化.结果COP后,血小板平均相对体积及血小板CD61的表达均显著升高(P＜0.05),而且持续15 d以上.HBO组较COP组血小板平均相对体积及血小板CD 61的表达较快恢复正常(P＜0.05).HPT组与COP组相比高气压对血小板平均相对体积及血小板CD 61的表达均无显著影响(P＞0.05).结论ACOP可导致血小板活性增加并持续.HBO治疗可以使其较快恢复正常.
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