You Position: Home > Paper
Effects of hyperbaric oxygen on the expression of platelet membrane glycoprotein-CD31,CD61 and CD62p in mice after cerebral ischemia-reperfusion
( views:349, downloads:16 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-6906.2003.02.008
- Key Word:
- 高压氧;脑缺血再灌注;血小板膜糖蛋白
Abstract： 目的研究高压氧(HBO)对脑缺血再灌注小鼠血小板膜糖蛋白的影响.方法小鼠随机分为HBO组、高气压组、单纯缺血再灌注组、假手术组和正常对照组.夹闭小鼠双侧颈总动脉,建立脑缺血再灌注动物模型.应用流式细胞术分别检测再灌注后第1,3,5天的血小板膜糖蛋白CD31、CD61和CD62p的表达.结果 HBO组第1,3天的血小板膜糖蛋白CD31表达水平显著低于同期再灌注组(均P＜0.05);HBO组第1天的CD61、CD62p表达水平显著低于同期再灌注组(均P＜0.05).HBO组、高气压组、单纯缺血再灌注组第5天的血小板膜糖蛋白CD31、CD61和CD62p表达均恢复正常水平.结论早期HBO治疗可有效抑制缺血再灌注后血小板膜糖蛋白CD31、CD61和CD62p的表达,可能有助于减轻再灌注损伤.
- [1]刘育英,赵秀梅,刘凤英,等.缺血再灌脑血管内皮损伤及GP Ⅲ a表达的研究[J].2000,(3).
- [2]V L, Serebruany,P A, Gurbel.Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction.[J].1999,19.
- [3]赵旸,于龙顺,谭艳,等.神经节苷脂GM1对小鼠脑缺血复灌后记忆障碍的实验治疗作用[J].1999,(6).
- [4]杨金升,高福兴,张如富.急性脑缺血时内皮素和血小板膜糖蛋白的变化[J].1996,(5).
- [5]S, Massberg,G, Enders,R, Leiderer,etc.Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin.[J].1998,92.
- [6]Verstraete M.Synthetic inhibitors of platelet glycoprotein IIb/IIIa in clinical development.[J].2000,101(6).
- [7]王振义，李家增，阮长耿主编.血栓与止血:基础理论与临床[M].1996.
- [8]Michelson AD,Furman MI.Laboratory markers of platelet activation and their clinical significance.[J].1999,6(5).
- [9]X W, Wu,E C, Lian.Binding properties and inhibition of platelet aggregation by a monoclonal antibody to CD31 (PECAM-1).[J].1997,17.
- [10]Luis de-la-Pompa-J,Zukowski MM,Duncan GS,etc.Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.[J].1999,162(5).