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Influences of dimethyl sulfoxide on glutamic acid-induced injury of rat's hippocampal slices
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2002.04.001
- Key Word:
- 二甲亚砜;海马脑片;顺向群峰电位;谷氨酸;兴奋性毒性
Abstract： 目的观察二甲亚砜(DMSO)对大鼠海马脑片谷氨酸(Glu)兴奋性毒性损伤的影响,以探讨其保护作用与剂量的关系.方法在离体海马脑片灌流液中加入Glu造成兴奋性毒性损伤,用电生理记录技术观察不同浓度的DMSO对海马脑片顺向群峰电位(OPS)的影响.结果去除Glu 1 h后,DM-SO(0.07 mol/L)组OPS恢复幅度和恢复率分别为(88.2±22.9)%,83.3%,与对照组相比差异有显著性意义(P＜0.05),而且DMSO组OPS恢复幅度具有剂量依赖性.结论DMSO具有抗谷氨酸兴奋性神经毒性作用,且这一作用与所用剂量有关.
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