You Position: Home > Paper
Effect of hyperbaric oxygen on the expression of platelet CD61 and polymorphonuclear leukocyte adhesion molecules CD11b/CD18 of peripheral blood in carbon monoxide poisoning rats
( views:252, downloads:16 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-6906.2002.03.002
- Key Word:
- 高压氧;一氧化碳中毒;多形核白细胞粘附分子
Abstract： 目的观察高压氧(HBO)对一氧化碳中毒大鼠外周血血小板CD61及多形核白细胞粘附分子CD11b/CD18表达的影响.方法健康成年Wistar大鼠共128只,动物被随机分成4组.正常对照组8只;一氧化碳中毒组(COP)40只,按观察时程,第1,5,10,15,20天各8只;高气压处理组(HPT)共40只,第1,5,10,15,20天各8只;高压氧组(HBO)40只,第1,5,10,15,20天各8只.用流式细胞仪测定CO中毒大鼠在不同时间段外周血血小板CD61及多形核白细胞粘附分子CD11b/CD18的表达.结果 COP中毒后1,5,10 d COP及HPT组大鼠外周血血小板CD61表达量明显高于对照组,而HBO组仅在第1天高于对照组.外周血多形核白细胞粘附分子CD11b/CD18的表达量的变化为,COP组大鼠在CO中毒后第1,5,10,15,20天及HPT组大鼠在CO中毒后第1,5,10,15天明显高于对照组,而HBO组其值在CO中毒后第1,5,10天高于对照组.结论 CO中毒后大鼠外周血血小板CD61及多形核白细胞粘附分子CD11b/CD18的表达增高并持续一段时间,HBO治疗使其增高的时间明显缩短.
- [1]William,Zamboni Allan,Roth Robert,etc.Morphologic Analysis of the Microcirculation During Reperfusion of Ischemic Skeletal Muscle and the Effect of Hyperbaric Oxygen[J].1993,91(6).
- [2]高春锦,赵立明,夏成清.高压氧对CO中毒大鼠海马中钙离子cGMP及血浆NO含量的影响[J].1999,(4).
- [3]Wenche Jy,Wei-Wei Mao,Lawrence L. Horstman,etc.Platelet Microparticles Bind, Activate and Aggregate Neutrophils In Vitro[J].1995,21(3).
- [4]P. Toft,C. Nielsen,E. Tø,etc.Changes in adhesion molecule expression and oxidative burst activity of granulocytes and monocytes during open-heart surgery with cardiopulmonary bypass compared with abdominal surgery[J].1998,15(3).
- [5]Wim Timens.Cell adhesion molecule expression and homing of hematologic malignancies[J].1995,19(2).
- [6]刘建东,唐汝愚.地塞米松抑制白细胞功能防治大鼠脑缺血性损伤研究[J].1995,(1).
- [7]高春锦.实用高压氧学[M].1998.
- [8]van Kooten F.,Ciabattoni G.,Patrono C.,etc.Evidence for episodic platelet activation in acute ischemic stroke[J].1994.
- [9]van Kooten F.,Ciabattoni G.,Patrono C.,etc.Platelet Activation and Lipid Peroxidation in Patients With Acute Ischemic Stroke[J].1997.
- [10]I S, Choi.Delayed neurologic sequelae in carbon monoxide intoxication.[J].1983,40.
- [11]U. Fiszer,G. Korczak-Kowalska,W. Palasik,etc.Increased expression of adhesion molecule CD18 (LFA-1β) on the leukocytes of peripheral blood in patients with acute ischemic stroke[J].1998,97(4).