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Effect of seawater immersion on plasma MDA and SOD levels in dogs with open celiac wound
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-6906.2001.03.006
- Key Word:
- 腹部外伤;海水浸泡;自由基
Abstract： 目的了解腹腔开放伤后海水浸泡对机体血浆中自由基水平的影响.方法 28只犬随机均分为对照组(A组)、单纯腹部浸泡组(B组)、腹腔等渗盐水浸泡组(C组)和腹腔海水浸泡组(D组)4个组.A组为单纯腹外伤,B组为直接将犬无伤腹部浸入海水中浸泡处理,C、D两组犬致伤后分别置入等渗盐水或海水中浸泡处理,观察血浆中丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxidedismutase,SOD)及血浆渗透压的变化.结果犬腹腔开放伤并海水浸泡后60min时,血浆中MDA与血浆渗透压水平显著升高(与浸泡前及A、B、C组比较,P<0.01),并随浸泡时间延长呈升高趋势;而同时SOD水平则显著降低(与浸泡前及A、B、C组比较,P<0.01),并随浸泡时间延长呈降低趋势.浸泡处理前后A、B、C组间差别未见有显著性(P>0.05).结论腹腔开放伤区海水浸泡可引起机体自由基水平升高.
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