You Position: Home > Paper
The changes of TXB2 and 6-Keto-PGF1α in the myocardium with relation to blood-gas after hypothermic sea water near drowning in rats
( views:240, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-6906.2001.02.001
- Key Word:
- 低温海水;淹溺;血栓素B2;6-酮-前列腺素F1α
Abstract： 目的探讨低温海水淹溺大鼠心肌TXB2、6-Keto-PGF1α及TXB2/6-Keto-PGF1α(T/K)与血气的关系.方法将淹溺组大鼠置于低温(16～18℃)海水中,任其自由游动直至沉入水底,呼吸暂停,迅速取出置室温下观察,分别于5,15,30,60,240,360 min(每小组各6只)测大鼠肛温,取左心血行血气分析,取各小组4只检测心肌组织TXB2及6-Keto-PGF1α含量,观察T/K变化,肺组织计算干重/湿重比值(D/W),另2只光镜下观察肺脏及心脏形态改变.结果淹溺大鼠肛温、pH、PaO2及6-Keto-PGF1α明显降低,于5 min组降至最低点(P＜0.01),PaCO2及TXB2则明显上升,分别于5 min组及30min组升至最高点(P＜0.01),T/K比值明显上升;淹溺后随离海水的时间延长,肛温、pH、PaO2及Pa-CO2呈恢复趋势,心肌的TXB2、6-Keto-PGF1α及T/K比值则无明显改善.结论低温海水淹溺大鼠心肌的TXB2及6-Keto-PGF1α含量受低温、低氧血症及酸中毒的影响,造成TXB2增高、6-Keto-PGF1α降低及T/K比值失衡从而使心脏功能趋于恶化.
- [1]董文度,张敏华,董敏,等.海水淹溺肺水肿兔血浆前列腺素和心房利钠多肽的变化[J].1999,(2).
- [2]Hanamura T.,Shigeno T.,Asano T.,etc.Prostaglandin profiles in relation to local circulatory changes following focal cerebral ischemia in cats[J].1989.
- [3]李继红,辛火,朱国标,等.热暴露附加运动负荷对血浆TXB2,6-K-PGF1_A比值及心肌细胞超微结构的影响[J].1995,(1).
- [4]李振甲, 王仁芝主编.激素的放射免疫分析[M].1985.
- [5]董文度,喻方迩,余有训,等.绵羊海水溺水模型血浆前列腺素与低氧血症的关系[J].1994,(4).
- [6]张敏华.高频喷射通气对海水淹溺肺水肿兔血气指标和前列腺素的影响[J].1999,(3).