Study the feasibility of kilovolt cone beam CT organs at risk contouring automatically using deformation registration in the radiotherapy of lung

( views:290, downloads:0 )
Author:
HOU Yong(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology;Shandong Academy of Medical Sciences Ji' nan 250117,China)
YIN Yong(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology;Shandong Academy of Medical Sciences Ji' nan 250117,China)
MA Chang-sheng(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology;Shandong Academy of Medical Sciences Ji' nan 250117,China)
GONG Guan-zhong(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology;Shandong Academy of Medical Sciences Ji' nan 250117,China)
Journal Title:
Chinese Journal of Radiation Oncology
Issue:
Volume 21, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1004-4221.2012.05.019
Key Word:
Tomography, X-ray computed;Tomography, X-ray computed, cone beam;Image registration;Delineating organs at risk

Abstract: Objective To quantitative analysis the difference of organ contour using planning CT and kilovolt cone beam CT (KVCBCT) deformable registration.Methods One set planning CT image and ten sets of KVCBCT image of one patient were choose and total five patients.Organ contour were automatic outlined to using deformable registration.To compare the organ contours different of deformable registration (DR) and rigid registration (RR).Statistic analysis was executed with paired t-test for dice similarity coefficient (DSC) value and sensitiveness (SENS) value.Results The DSC value of body,left,right lung,heart and spinal respectively:0.971 and 0.980 ( t =3.89,P =0.000 ),0.836 and 0.873 ( t =4.41,P =0.000),0.873 and 0.888 ( t =3.88,P =0.000 ),0.738 and 0.764 ( t =4.83,P =0.000 ),0.666 and 0.677 ( t =2.04,P =0.047 ).The SENS value:0.975 and 0.981 ( t =1.41,P =0.003 ),0.914 and 0.803(t=-6.88,P=0.000),0.926 and 0.800(t=-7.06,P=0.045),0.782 and 0.708(t=-2.50,P=0.040),0.625 and 0.796 (t =-9.09,P =0.000).Conclusions RR is at a competitive disadvantage in terms of organ contour outline.The body,left and right lung that are used DR have advantage over the heart and spinal.

  • [1]Lian J,Xing L,Hunjan S,Dumoulin C,et at.Mapping of the prostate in end rectal coil-based MRI/MRSI and CT:a deformable registration and validation study.Med Phys,2004,31:3087-3094.
  • [2]Wu X, Dibiase S, Gullapalli R, et al.Deformable image registration forth use of magnetic resonance spectroscopy in prostate treatment planning.Int J Radiat Oncol Biol Phys,2004,58:1577-1583.
  • [3]Yan D,Vicini F,Wong J,et al.Adaptive radiation therapy.Phys Med Biol,1997,42:12-32.
  • [4]Matsopoulos G,Mouravliansky N,Asvestas P,et al.Thoracic deformable,registration combining self-organizing maps and radial basis functions.Med Image Anal,2005,9:237-254.
  • [5]Slomka P, Dey D, Przetak C, et al. Automated 3-dimensionalregistration of stand-alone (18) F-FDG whole-body PET with CT.J Nucl Med,2003,44:1156-1467.
  • [6]Stroom JC,Heijmen BJ.Geometrical uncertainties,radiotherapy planning margins,and the ICRU-62 report.Radiother Oncol,2002,64:75-83.
  • [7]李洪升,李宝生,卢洁,等.肺肿瘤在线与离线结合锥形束CT图像引导放疗的可行性研究.中华放射肿瘤学杂志,2009,18:130-133.
  • [8]Orban de Xivry J,Janssens G,Bosmans G,et al.Tumour delineation and cumulative dose computation in radiotherapy based on deformable registration of respiratory correlated CT images of lung cancer patients.Radiother Oncol,2007,85:232-238.
  • [9]Th(o)rnqvist S,Petersen JB,H(Φ)yer M,et al.Propagation of target and organ at risk contours in radiotherapy of prostate cancer using deformable image registration.Acta Oncologica,2010,49:1023-1032.
  • [10]Dice LR.Measures of the amount of ecologic association between species.Ecology,1945,26:297-302.
  • [11]江波,戴建荣.锥形束CT成像技术及其在放疗中的应用.中华放射肿瘤学杂志,2010,19:158-161.
  • [12]徐寿平,马林,杜镭,等.图像引导放疗进展-自适应螺旋断层治疗.中华放射肿瘤学杂志,2011,21:75-79.
  • [13]Barker JL Jr,Garden AS,Ang KK,et al.Quantifi cation of volumetric and geometric changes occurring during fractionated radiotherapy for head and neck cancer using an integrated CT/linear accelerator system.Int J Radiat Oncol Biol Phys,2004,59:960-970.
  • [14]Greco C, Ling CC.Broadening the scope of image-guided radiotherapy (IGRT).Acta Oncol,2008,47:1193-1200.
  • [15]Jaffray DA,Siewerdsen JH,Wong JW,et al.Flat-panel cone-beam computed tomography for image-guided radiation therapy.Int J Radiat Oncol Biol Phys,2002,53:1337-1349.
  • [16]Verellen D,De Ridder M,Tournel K,et al.An overview of volumetric imaging technologies and their quality assurance for IGRT.Acta Oncol,2008,47:1271-1278.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn