Clinical observation on the therapeutic efficacy of cyberknife for primary or metastastic retroperitoneal tumors

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ZHUANG Hong-qing(Department of Radiation Oncology, Cancer Hospital of Tianjin Medical University, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)
YUAN Zhi-yong(Department of Radiation Oncology, Cancer Hospital of Tianjin Medical University, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)
WANG Ping(Department of Radiation Oncology, Cancer Hospital of Tianjin Medical University, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)
Journal Title:
Chinese Journal of Radiation Oncology
Volume 21, Issue 05, 2012
Key Word:
Retroperitoneal neoplasms/radiotherapy;Radiotherapy, Cyberknife;Prognosis

Abstract: Objective To evaluate the early response rate and radiation toxicity of cyberknife in the treatment of primary or metastastic retroperitoneal tumors.Methods Twenty-eight patients with retroperitoneal tumors were treated with cyberknife.The total doses were 2000-6000 cGy ( median 4500 cGy) and biological effective doses were 3750-10080 cGy (median 7680 cGy) in 2-10 fractions (median 5).Of all patients,3 received three dimensional conformal radiotherapy (3DCRT) or intensity modulated radiotherapy (IMRT) boost,1 was treated as second-course radiotherapy,and others were treated with cyberknife only.The survival rates were calculated by Kaplan-Meier method and compared with Logrank test.Results The complete response,partial response,stable disease and progression disease rates were 43%(12/28),6% ( 10/28),18% ( 5/28 ),4% ( 1/28 ),respectively.The overall response rate was 96%.The number of patients who were followed up more than 1,2,3 years were 17,9,7,respectively.The 1-,2-and 3-year local control rates were 92%,86% and 86%,respectively.The 1-,2-and 3-year overall survival rates were 60%,49% and 49%,respectively.The difference between local progression-free survival and overall survival was not significant ( median 9.5 and 12.0 months,x2 =0.17,P =0.680).Moreover,if the patients did not have metastasis elsewhere and local treatment was effective,there was no significant difference between local progression-free survival and progression free survival (median 17 and 11 months,x2 =0.13,P=0.720).Acute radiation-induced side effects (≥ 2 grade) such as fatigue,anorexia,nausea,vomiting and epigastric discomfort occurred in 9,9,7,7 and 2 patients,respectively.Intestinal stenosis of 1 grade occurred in 1 patient.Conclusions Radiotherapy for retroperitoneal tumors with cyberknife has provided a high response rate with minimal side effects.It is a safe and effective local treatment method for retroperitoneal tumors.

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